Public Announcement: Genome assembly experts - who wants to handle Raj’s question on 3GB mammalian genome assembly? It combines all complexities of modern genome assembly including multiple technologies, pacbio and so on.
Three things to note in Deanna Church’s slides:
1. “The assembled genome is a model”. It is good that the point is increasingly being recognized by researchers.
2. Human genome is the most expensive and most thoroughly checked genome among all large ones. So, those working on any other genome sequence need to cautious before inferring anything based on the sequence.
3. “Rong Chen (Personalis): even when the same genome is sequenced twice using 50X Illumina, 6% of variants differ.”