Pevzner's Bioinformatics Course at Coursera Delayed by Two Weeks
Syllabus surely looks interesting and the week 1 version is shown below. By some strange coincidence, when we first dipped our toes into bioinformatics (mostly by working on papers), we also looked into the problem of DNA replication origin first.
Week 1: Where Does DNA Replication Begin? (Algorithmic Warmup)
Homework 1, due 28 October: Complete Chapter 1 of Bioinformatics Algorithms on Stepic
Detailed Topics:
Introduction to DNA Replication
Hidden Messages in the Replication Origin
Some Hidden Messages are More Surprising than Others
An Explosion of Hidden Messages
The Simplest Way to Replicate DNA
Asymmetry of Replication
Peculiar Statistics of the Forward and Reverse Half-Strands
Some Hidden Messages Are More Elusive than Others
A Final Attempt at Finding DnaA Boxes in E. Coli
Epilogue: Complications in oriC Predictions
Final Challenge: Find DnaA boxes in Salmonella enterica
Open Problems
Multiple Replication Origins in a Bacterial Genome
Finding Replication Origins in Draft Bacterial Genomes
Finding Replication Origins in Archaea
Finding Replication Origins in Yeast
Computing Exact Probabilities of Patterns in a String and the Overlapping Words Paradox
Detours
Big-O Notation
Probabilities of Patterns in a String
The Most Beautiful Experiment in Biology
Chemical Basis for Directionality of DNA Strands
The Overlapping Words Paradox
